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ABCB4 / MDR3

ATP-binding cassette, sub-family B (MDR/TAP), member 4

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Family/Subfamily: Transporter , ATP-binding cassette - ABCB/MDR
Synonyms: ABCB4, ABC21, ICP3, GBD1, MDR3, MDR2, Multidrug resistance protein 3, Multiple drug resistance 3, P-glycoprotein 3, Pgy2, PGY3, PFIC-3, MDR2/3
Target Sequences: NM_018849 NP_061337.1 P21439

Publications (3)

1
Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model. Weber ND, Odriozola L, Martínez-García J, Ferrer V, Douar A, Bénichou B, González-Aseguinolaza G, Smerdou C. Nature communications. 2019 December;10:5694. [Full Text Article] [PubMed:31836711] [PMC:PMC6910969] Related Antibodies: LS-B5729.
2
Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study. Kaan Kamali, Moritz Schmelzle, Can Kamali, Philipp Brunnbauer, Katrin Splith, Annekatrin Leder, Nadja Berndt, Karl-Herbert Hillebrandt, Nathanael Raschzok, Linda Feldbrügge, Matthäus Felsenstein, Joseph Gaßner, Paul Ritschl, Georg Lurje, Wenzel Schöning, Christian Benzing, Johann Pratschke, Felix Krenzien. Frontiers in immunology. 2021 May;12:647900. [Full Text Article] [PubMed:34025656] [PMC:PMC8131523] Related Antibodies: LS-C694886.
3
ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth. Kiehl S, Herkt SC, Richter AM, Fuhrmann L, El-Nikhely N, Seeger W, Savai R, Dammann RH. Scientific reports. 4:6899. [Full Text Article] [PubMed:25367630] [PMC:PMC4219162] Related Antibodies: LS-B5729.

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ABCB4 / MDR3 Protein - Recombinant ATP Binding Cassette Transporter B4 (ABCB4) by SDS-PAGE
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E. coli
His-T7, N-terminus
30.3kDa
10 µg/$272; 50 µg/$387; 200 µg/$772; 100 µg/$620; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016
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66.9 kD
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).