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ABCB1 / MDR1 / P Glycoprotein
ATP-binding cassette, sub-family B (MDR/TAP), member 1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
| Gene Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCB/MDR |
| Synonyms: | ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1 |
| Target Sequences: | NM_000927 NP_000918.2 P08183 |
Publications (6)
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