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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
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Unfortunately, the antibody (ID:92532) is no longer available.
Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page.
Please contact us if you have any questions.
AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 184.108.40.206): a new cell line (1E7) provides evidence of intracellular AANAT activation. Coon SL, Weller JL, Korf HW, Namboodiri MA, Rollag M, Klein DC. The Journal of biological chemistry. 2001 276:24097-107.
Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Iuvone PM, Brown AD, Haque R, Weller J, Zawilska JB, Chaurasia SS, Ma M, Klein DC. Investigative ophthalmology & visual science. 2002 43:564-72.
14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. Klein DC, Ganguly S, Coon S, Weller JL, Obsil T, Hickman A, Dyda F. Biochemical Society transactions. 2002 30:365-73.
Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 220.127.116.11). Coon SL, Del Olmo E, Young WS, Klein DC. The Journal of clinical endocrinology and metabolism. 2002 87:4699-706.
Arylalkylamine N-acetyltransferase: "the Timezyme". Klein DC. The Journal of biological chemistry. 2007 282:4233-7.