A2ML1

alpha-2-macroglobulin-like 1

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

A2ML1 (5)

Publications

No (5)

Tag

GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human A2ML1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

161 kDa

Price:

20 µg/$1,107

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Human A2ML1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94788

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

161 kDa

Price:

20 µg/$215

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Human A2ML1 Protein (Recombinant His-T7) (aa1119-1348) - LS-G13147

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.8 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human A2ML1 Protein (Recombinant GST) (Full Length) - LS-G36638

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.1 kDa

Price:

10 µg/$479; 25 µg/$670

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A2ML1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106923

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

161 kDa

Price:

100 µg/$710

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