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A2M / Alpha-2-Macroglobulin

alpha-2-macroglobulin

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene Name: alpha-2-macroglobulin
Synonyms: A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7
Target Sequences: NM_000014 NP_000005.2 P01023

Filtered By: None
Target
a2m-alpha-2-macroglobulin (176)
Reactivity
Human (94)
Mouse (35)
Rat (41)
Chimpanzee (3)
Dog (2)
Duck (3)
Gibbon (3)
Monkey (1)
Pig (12)
Rabbit (2)
Application
IHC (73)
IHC-Fr (2)
IHC-P (7)
WB (137)
Flo (1)
ELISA (62)
ICC (2)
ID (5)
IE (7)
IF (1)
IP (15)
Peptide-ELISA (1)
RIA (2)
Host
rabbit (116)
mouse (32)
goat (23)
chicken (1)
rat (2)
sheep (2)
Isotype
IgG (121)
IgG1 (4)
IgG1,k (6)
IgG2a (2)
IgG2a,k (1)
IgG2b,k (19)
IgM (1)
IgY (1)
Clonality
monoclonal mc (32)
polyclonal pc (144)
Clone
2B5 (1)
2D9 (1)
3127485 (1)
3D1 (1)
590CT15.5.5 (1)
9A3 (1)
A1 (8)
F1-P1C11 #3 (2)
SPM178 (3)
Format
AP Conjugated (3)
APC (10)
APC Conjugated (13)
Azide-free (2)
Biotin Conjugated (20)
Cy3 Conjugated (10)
Cy7 Conjugated (10)
FITC Conjugated (22)
HRP Conjugated (17)
PE Conjugated (13)
Unconjugated (68)
Epitope
aa1097-1357 (10)
aa157-389 (10)
aa818-1048 (10)
aa1053-1214 (9)
aa1162-1192 (9)
aa216-437 (9)
aa616-856 (9)
aa574-734 (8)
aa911-1042 (8)
aa93-120 (8)
aa259-308 (4)
C-Terminus (2)
Internal (2)
N-Terminus (1)
aa1100-1180 (1)
aa417-430 (1)
Publications
No (176)
Showing 1-25 out of 176 results
A2M / Alpha-2-Macroglobulin Antibody IHC-plus™ LS-B403
Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B403 concentration 5 ug/ml.
Alpha-2-Macroglobulin Polyclonal Antibody-Western blot. Goat anti-Alpha-2-Macroglobulin antibody (LS-B403 lot 20172) was used to detect Alpha-2-Macroglobulin under reducing (R) and non-reducing (NR) conditions. Reduced samples of purified target proteins contained 4% BME and were boiled for 5 minutes. Samples of ~1 ug of protein per lane were run by SDS-PAGE. Protein was transferred to nitrocellulose and probed with 1:3000 dilution of primary antibody (ON 4 C in MB-070). Detection shown was using Dylight 649 conjugated Donkey anti-goat (1:10K in TBS/MB-070) 1 hr RT. Images were collected using the BioRad VersaDoc System.

Goat Polyclonal to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC IHC-P IP WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (C-Terminus) LS-C46958

Rabbit Polyclonal to Human A2M / Alpha-2-Macroglobulin
Human
ELISA WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (C-Terminus) IHC-plus™ LS-B3119
Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3119 concentration 10 ug/ml.

Rabbit Polyclonal to Human A2M / Alpha-2-Macroglobulin
Rat, Human
ELISA IHC IHC-P WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody LS-C61991
Western blot Image

Mouse Monoclonal (IgG1,k) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (HRP) LS-C25313

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Rabbit, Dog, Pig, Human
ELISA IE
HRP Conjugated
A2M / Alpha-2-Macroglobulin Antibody (Biotin) LS-C125899

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ICC WB
Biotin Conjugated
A2M / Alpha-2-Macroglobulin Antibody IHC-plus™ LS-B8038
Anti-Alpha-2-Macroglobulin / A2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8038 dilution 5 ug/ml.

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Rabbit, Dog, Pig, Human
ELISA IE IHC IHC-P IP
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody IHC-plus™ LS-B12816
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Sheep Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC IHC-Fr IHC-P
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody IHC-plus™ LS-B4881
Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4881 concentration 3.75 ug/ml.
Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4881 concentration 3.75 ug/ml.

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC IHC-P IP WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody LS-C71927

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (aa1053-1214) LS-C292754
Western blot of recombinant Alpha-2-Macroglobulin / A2M.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse A2M / Alpha-2-Macroglobulin
Mouse
IHC WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (aa911-1042, Biotin) LS-C299862
Western blot of recombinant Alpha-2-Macroglobulin / A2M.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse A2M / Alpha-2-Macroglobulin
Mouse
IHC WB
Biotin Conjugated
A2M / Alpha-2-Macroglobulin Antibody (aa417-430) IHC-plus™ LS-B11265
Anti-A2M / Alpha-2-Macroglobulin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11265 concentration 5 ug/ml.
Anti-A2M / Alpha-2-Macroglobulin antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Goat Polyclonal to Human A2M / Alpha-2-Macroglobulin
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody LS-C125898

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA Flo ICC IP WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody IHC-plus™ LS-B12228
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IE IHC IHC-P
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (Internal) LS-C387140
Immunohistochemistry of Macroglobulin alpha-2 antibody
Immunohistochemistry of Macroglobulin alpha-2 antibody

Rabbit Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody LS-C677026
Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue at dilution of 1:100

Rabbit Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IF IHC
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody LS-C659317

Rabbit Polyclonal (IgG2a) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC IP WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody LS-C659319

Mouse Monoclonal (IgG2a) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (HRP) LS-C187665
Human alpha-2 Macroglobulin detected with Sheep anti-alpha-2 Macroglobulin:HRP This image was taken for the unconjugated form of this product. Other forms have not been tested.

Sheep Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA ID IHC IHC-Fr
HRP Conjugated
A2M / Alpha-2-Macroglobulin Antibody (aa157-389) LS-C292747
Western blot of recombinant Alpha-2-Macroglobulin / A2M.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse A2M / Alpha-2-Macroglobulin
Mouse
IHC WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (aa911-1042) LS-C292753
Western blot of recombinant Alpha-2-Macroglobulin / A2M.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse A2M / Alpha-2-Macroglobulin
Mouse
IHC WB
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (aa1100-1180) LS-C384421

Rabbit Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IHC
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (clone F1-P1C11 #3) LS-C355390

Mouse Monoclonal [clone F1-P1C11 #3] (IgG1) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IP RIA
Unconjugated
A2M / Alpha-2-Macroglobulin Antibody (clone F1-P1C11 #3) LS-C355232

Mouse Monoclonal [clone F1-P1C11 #3] (IgG1) to Human A2M / Alpha-2-Macroglobulin
Human
ELISA IP RIA
Unconjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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