Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
15-PGDH / HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
15-PGDH / HPGD is a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
Monoclonal antibodies that inhibit the enzyme activity of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Tai CL, Mak OT, Arai T, Tai HH. The Biochemical journal. 1990 267:75-8. (Human)
[PubMed:1691637]
[PMC:PMC1131246]
2
Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. Tong M, Tai HH. Endocrinology. 2004 145:2141-7.
[PubMed:14749354]
3
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. Ding Y, Tong M, Liu S, Moscow JA, Tai HH. Carcinogenesis. 2005 26:65-72.
[PubMed:15358636]
4
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN. The Journal of biological chemistry. 2005 280:3217-23.
[PubMed:15542609]
[PMC:PMC1847633]
5
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:17468-73.
[PubMed:15574495]
[PMC:PMC536023]
6
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW, Dey SK, DuBois RN. Cancer research. 2006 66:6649-56.
[PubMed:16818638]
7
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Cancer research. 2008 68:9331-7.
[PubMed:19010907]
[PMC:PMC2628771]
8
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Hughes D, Otani T, Yang P, Newman RA, Yantiss RK, Altorki NK, Port JL, Yan M, Markowitz SD, Mazumdar M, Tai HH, Subbaramaiah K, Dannenberg AJ. Cancer prevention research (Philadelphia, Pa.). 2008 1:241-9.
[PubMed:19138967]
[PMC:PMC2720569]
9
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes. Miyaki A, Yang P, Tai HH, Subbaramaiah K, Dannenberg AJ. American journal of physiology. Gastrointestinal and liver physiology. 2009 297:G559-66.
[PubMed:19608733]
[PMC:PMC2739822]
10
UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression. Judson BL, Miyaki A, Kekatpure VD, Du B, Gilleaudeau P, Sullivan-Whalen M, Mohebati A, Nair S, Boyle JO, Granstein RD, Subbaramaiah K, Krueger JG, Dannenberg AJ. Cancer prevention research (Philadelphia, Pa.). 2010 3:1104-11. (WB; Human)
[PubMed:20643784]
[PMC:PMC2933319]
11
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue. Gheorghe KR, Sadique S, Leclerc P, Idborg H, Wobst I, Catrina AI, Jakobsson PJ, Korotkova M. Arthritis research & therapy. 2012 14:R121. (ICC, IHC-Fr; Human)
[PubMed:22616846]
[PMC:PMC3446502]
12
Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer. Kang PS, Kim JH, Moon OI, Lim SC, Kim KJ. Journal of the Korean Society of Coloproctology. 2012 28:253-8. (IHC; Human)
[PubMed:23185705]
[PMC:PMC3499426]
13
Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Li C, Singh B, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Bogatcheva G, Khan MP, Milne GL, Zhao S, Ayers GD, Li N, Hu H, Washington MK, Yeatman TJ, McDonald OG, Liu Q, Coffey RJ. Proceedings of the National Academy of Sciences of the United States of America. 2017 114:E2852-E2861. (WB; Human)[Full Text Article]
[PubMed:28320945]
[PMC:PMC5389279]
Related Antibodies: LS-C172619.
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).
