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15-PGDH / HPGD

hydroxyprostaglandin dehydrogenase 15-(NAD)

15-PGDH / HPGD is a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: hydroxyprostaglandin dehydrogenase 15-(NAD)
Synonyms: HPGD, 15-PGDH, PGDH, PGDH1, PHOAR1, Prostaglandin dehydrogenase 1, SDR36C1
Target Sequences: NM_000860 NP_000851.2 P15428

Publications (13)

1
Monoclonal antibodies that inhibit the enzyme activity of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Tai CL, Mak OT, Arai T, Tai HH. The Biochemical journal. 1990 267:75-8. (Human) [PubMed:1691637] [PMC:PMC1131246]
2
Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. Tong M, Tai HH. Endocrinology. 2004 145:2141-7. [PubMed:14749354]
3
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. Ding Y, Tong M, Liu S, Moscow JA, Tai HH. Carcinogenesis. 2005 26:65-72. [PubMed:15358636]
4
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN. The Journal of biological chemistry. 2005 280:3217-23. [PubMed:15542609] [PMC:PMC1847633]
5
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:17468-73. [PubMed:15574495] [PMC:PMC536023]
6
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW, Dey SK, DuBois RN. Cancer research. 2006 66:6649-56. [PubMed:16818638]
7
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Cancer research. 2008 68:9331-7. [PubMed:19010907] [PMC:PMC2628771]
8
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Hughes D, Otani T, Yang P, Newman RA, Yantiss RK, Altorki NK, Port JL, Yan M, Markowitz SD, Mazumdar M, Tai HH, Subbaramaiah K, Dannenberg AJ. Cancer prevention research (Philadelphia, Pa.). 2008 1:241-9. [PubMed:19138967] [PMC:PMC2720569]
9
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes. Miyaki A, Yang P, Tai HH, Subbaramaiah K, Dannenberg AJ. American journal of physiology. Gastrointestinal and liver physiology. 2009 297:G559-66. [PubMed:19608733] [PMC:PMC2739822]
10
UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression. Judson BL, Miyaki A, Kekatpure VD, Du B, Gilleaudeau P, Sullivan-Whalen M, Mohebati A, Nair S, Boyle JO, Granstein RD, Subbaramaiah K, Krueger JG, Dannenberg AJ. Cancer prevention research (Philadelphia, Pa.). 2010 3:1104-11. (WB; Human) [PubMed:20643784] [PMC:PMC2933319]
11
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue. Gheorghe KR, Sadique S, Leclerc P, Idborg H, Wobst I, Catrina AI, Jakobsson PJ, Korotkova M. Arthritis research & therapy. 2012 14:R121. (ICC, IHC-Fr; Human) [PubMed:22616846] [PMC:PMC3446502]
12
Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer. Kang PS, Kim JH, Moon OI, Lim SC, Kim KJ. Journal of the Korean Society of Coloproctology. 2012 28:253-8. (IHC; Human) [PubMed:23185705] [PMC:PMC3499426]
13
Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Li C, Singh B, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Bogatcheva G, Khan MP, Milne GL, Zhao S, Ayers GD, Li N, Hu H, Washington MK, Yeatman TJ, McDonald OG, Liu Q, Coffey RJ. Proceedings of the National Academy of Sciences of the United States of America. 2017 114:E2852-E2861. (WB; Human) [Full Text Article] [PubMed:28320945] [PMC:PMC5389279] Related Antibodies: LS-C172619.
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Antibodies (54)
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15-PGDH / HPGD (67)
Human (50)
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15-PGDH / HPGD Antibody - Anti-HPGD / 15-PGDH antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 ml/$460
15-PGDH / HPGD Antibody - Anti-HPGD / 15-PGDH antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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15-PGDH / HPGD Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HPGD mouse monoclonal antibody.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (OTI2C10) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HPGD mouse monoclonal antibody.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (Carrier-free) (OTI2C10) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
15-PGDH / HPGD Antibody - Anti-HPGD / 15-PGDH antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Rabbit, Guinea pig, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
1 Each/$485
15-PGDH / HPGD Antibody - Western blot analysis of extracts of various cell lines.
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15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HPGD mouse monoclonal antibody.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (OTI1C10) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HPGD mouse monoclonal antibody.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (Carrier-free) (OTI1C10) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
15-PGDH / HPGD Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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15-PGDH / HPGD Rabbit anti-Human Polyclonal (aa205-266) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
15-PGDH / HPGD Antibody - Anti-HPGD / 15-PGDH antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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15-PGDH / HPGD Goat anti-Human Polyclonal (aa255-266) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
15-PGDH / HPGD Antibody - Immunohistochemistry of paraffin-embedded human lung cancer using HPGD Antibody at dilution of 1:100
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15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-HPGD mouse monoclonal antibody.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (OTI2F5) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-HPGD mouse monoclonal antibody.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (Carrier-free) (OTI2F5) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Human prostate tissue using anti-HPGD mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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15-PGDH / HPGD Mouse anti-Human Monoclonal (OTI1E9) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
15-PGDH / HPGD Antibody - IHC of paraffin-embedded Human prostate tissue using anti-HPGD mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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15-PGDH / HPGD Mouse anti-Human Monoclonal (Carrier-free) (OTI1E9) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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15-PGDH / HPGD Rabbit anti-Human Monoclonal (Preservative Free) (004) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
15-PGDH / HPGD Antibody - HPGD Antibody IHC of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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15-PGDH / HPGD Rabbit anti-Human Polyclonal (aa184-212) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$649
Select
15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
Select
15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
Select
15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
Select
15-PGDH / HPGD Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
100 µl/$412
15-PGDH / HPGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HPGD (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HPGD.
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15-PGDH / HPGD Mouse anti-Human Monoclonal (OTI1C12) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
15-PGDH / HPGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HPGD (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HPGD.
Select
15-PGDH / HPGD Mouse anti-Human Monoclonal (Carrier-free) (OTI1C12) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
15-PGDH / HPGD Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using HPGD Polyclonal Antibody at dilution of 1:30.
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15-PGDH / HPGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Viewing 1-25 of 67 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).