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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Results for "kinase inhibitor" Filtered by: None
Type
Chemical (67)
Chemical, Inhibitor (13)
Synthetic Peptide (6)
CAS Number
1019206-88-2 (1)
1025065-69-3 (1)
1049738-54-6 (1)
1125593-20-5 (1)
113276-94-1 (1)
116700-36-8 (1)
1202916-90-2 (1)
130964-39-5 (1)
1338247-35-0 (1)
1410880-22-6 (1)
1589527-65-0 (1)
15966-93-5 (1)
179248-59-0 (1)
182683-50-7 (1)
195371-52-9 (1)
199986-75-9 (1)
204005-46-9 (1)
211555-04-3 (1)
213743-31-8 (1)
219138-24-6 (1)
222035-13-4 (1)
224579-74-2 (1)
227449-73-2 (1)
265312-55-8 (1)
269390-69-4 (1)
269390-77-4 (1)
288144-20-7 (1)
301305-73-7 (1)
301836-43-1 (1)
303727-31-3 (1)
306301-68-8 (1)
312636-16-1 (2)
312917-14-9 (1)
331770-21-9 (1)
345987-15-7 (1)
349087-34-9 (1)
356559-20-1 (1)
359886-84-3 (1)
371943-05-4 (1)
396129-53-6 (1)
40254-90-8 (1)
443797-96-4 (1)
443798-47-8 (1)
4506-66-5 (1)
457081-03-7 (1)
478482-75-6 (1)
487021-52-3 (1)
491871-58-0 (1)
509093-47-4 (1)
516480-79-8 (1)
546102-60-7 (1)
577779-57-8 (1)
581098-48-8 (1)
587871-26-9 (1)
608512-97-6 (1)
622387-85-3 (2)
627536-09-8 (1)
658084-23-2 (1)
726695-51-8 (1)
7272-84-6 (1)
799764-07-1 (1)
811803-05-1 (1)
82801-73-8 (2)
862812-98-4 (1)
869288-64-2 (1)
871307-18-5 (1)
894804-07-0 (1)
905973-89-9 (1)
913844-45-8 (1)
918505-84-7 (1)
93076-89-2 (1)
934358-00-6 (1)
948557-43-5 (2)
99534-03-9 (1)
Biological Function
, and cell death. inhibiting this pathway is one strategy implemented to increase the therapeutic capacity of certain genotoxic anti-cancer regimens by sensitizing cancer cells to these agents. in prematurely senescent breast, lung, and colon cancer cells (1)
2, also known as kdr and flk1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to vegf isoforms a, c, and d. (1)
3-(4-pyridyl)indole is a rock-I inhibitor (ic50 = 25 µm) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay, 3-(4-Pyridyl)indole also inhibits rock-ii and prk2, another rho-depe (1)
A Cdk2 inhibitor. (1)
A cell-permeable FLT3 inhibitor. (1)
A cell-permeable inhibitor of Cdk1 and Cdk2. (1)
A cell-permeable p38 MAP kinase inhibitor. (1)
A cGMP-dependent protein kinase inhibitor. (1)
A DGK inhibitor. (1)
A dual inhibitor of CDKs and Aurora kinases. (1)
A non-selective JNK inhibitor. (1)
A pan-JAK inhibitor. (1)
A Pim-1 kinase inhibitor. (1)
A potent inhibitor of p38 MAP kinase. (1)
A potent inhibitor of Pim kinases. (1)
A potent inhibitor of Src kinases. (1)
A potent inhibitor of TGF-Beta R1/ALK5 kinase. (1)
A potent JNK inhibitor used in cells and animals. (1)
A potent PKA inhibitor. (1)
A potent, cell-permeable inhibitor of VEGFR2. (1)
A potent, inhibitor of PI3Ka. (1)
A potent, nonspecific kinase inhibitor. (2)
A potent, reversible inhibitor of p38a MAPK. (1)
A potent, selective inhibitor of c-Met. (1)
A reversible inhibitor of Tpl2. (1)
A selective blocker of spleen tyrosine kinase activity. (2)
A selective DNA damage control kinase inhibitor. (1)
A selective focal adhesion kinase inhibitor. (1)
A selective inhibitor of Cdk1 and Cdk5. (1)
A selective inhibitor of GSK3Beta. (1)
A selective inhibitor of JNK2 and JNK3. (1)
A selective inhibitor of lymphocyte-specific protein tyrosine kinase. (1)
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK. (1)
A selective sphingosine kinase inhibitor. (1)
A selective, cell-permeable inhibitor of MLCK. (1)
A selective, irreversible JNK inhibitor. (1)
A substrate-competitive inhibitor of PKCTheta activity. (2)
A synthetic peptide inhibitor of PKA. (1)
A tyrosine kinase inhibitor. (1)
An ATM kinase inhibitor. (1)
An ERK inhibitor. (1)
An inhibitor of casein kinase 2. (1)
An inhibitor of double-stranded RNA-activated protein kinase. (1)
An inhibitor of GSK3Beta signaling. (1)
An inhibitor of KDR, FLT1, and c-Kit. (1)
An inhibitor of LIMK1 and LIMK2. (1)
An inhibitor of SETD8. (1)
An inhibitor of the FAK1. (1)
An orally-available inhibitor of the B-raf mutant B-RafV600E. (1)
ataxia-telangiectasia mutated (atm) and atm- and rad3-related (atr) kinases mediate the dna damage response pathway in cells upon encounter with genotoxic agents. their signaling can activate cell cycle arrest, dna repair, induction of premature senescence (1)
Blocks Aurora A kinase activity. (1)
casein kinase 2 (ck2) is a constitutive protein kinase involved in many signal transduction pathways, 4,5,6,7-tetrabromobenzimidazole is a selective, atp-competitive inhibitor of ck2 with ki values ranging from 0.5-1 µm in rat liver, s, 4,5,6,7-Tetrabromob (1)
cdk4/6 inhibitor iv is a cell-permeable triaminopyrimidine that reversibly blocks cdk4/cyclin d1 and cdk6/cyclin d1 activity with ic50 values of 1.5 and 5.6 µm, respectively, cdk/6 inhibitor iv suppressed tumor growth after 29 days of treatment. (1)
cgk733 reportedly suppresses atm-mediated p21 expression required for survival, resulting in cell death. (1)
Competitive PKG inhibitor (1)
cx-6258 is a potent, reversible inhibitor of pim-1, -2, and -3 (ic50 s = 5, 25, and 16 nm, respectively), CX-6258 demonstrates excellent selectivity, inhibiting only flt3 from a panel of 107 additional kinases, cx-6258 is orally bioavailable and inhibits t (1)
enzimidazole is inactive against pka and pkc and a relatively weak inhibitor of ck1 (ki = 54.4-64.2 µm). (1)
he growth of mv4-11 xenografts in mice. (1)
Hsp25 Kinase Inhibitor (1)
IKK-e kinase inhibitor (1)
ility during tissue stress and trauma by negatively modulating intercellular signaling, adenosine kinase is the key metabolizing enzyme that regulates cellular adenosine concentrations. (1)
inhibition of adenosine kinase represents a mechanism to selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associated with the systemic administration of adenosine receptor agonists, aden (1)
Inhibitor of CK1 and ALK5. (1)
Inhibitor of interleukin-1 receptor associated kinase (IRAK) (1)
Inhibitor of TGF-Beta type-1 receptors. (1)
Inhibitor of VEGFR1, 2, and 3. (1)
mps1-in-1 is a selective inhibitor of monopolar spindle 1 (mps1) kinase (ic50 = 367 nm), a dual-specificity kinase involved in spindle assembly checkpoint and the maintenance of chromosomal stability. (1)
Multi-targeted inhibitor tyrosine kinase (1)
ndent kinase, with similar potency, while inhibiting msk-1 and pka with relatively weaker potency. (1)
Non-lipid pan-sphingosine kinase (SK) inhibitor (2)
on, sd 208 is a potent inhibitor of tgf-betari kinase (ec50 = 48 nm) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including tgf-betarii kinase, sd 208 is orally bioavailable and prevents tgf-beta-induced smad ph (1)
osine kinase inhibitor is a non-nucleoside pyridopyrimidine compound that blocks the action of adenosine kinase in an adenosine-competitive and reversible manner (ic50 = 1.7 nm in cell-free assays), adenosine provides homeostatic reductions in cell excitab (1)
osphorylation in spleens and brains of mice, sd 208 also suppresses tgf-beta-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of tgf-beta. (1)
PKA Inhibitor [6-22] Peptide is a potent and competitive inhibitor of protein kinase a (pka) with a ki = 1.7 nm, PKA Inhibitor [6-22] Peptide is amidated at the c-terminus end, pki-alpha interacts with the catalytic subunit of pka after the camp-induced di (1)
pkcalpha (c2-4) inhibitor peptide is a synthetic peptide that blocks pkc activity in hepg2 cells stimulated with calcium and pancreastatin when applied at 10 µm. (1)
Potent and reversible Syk inhibitor (1)
Potent and selective Tie2 inhibitor with IC50 of 0.25 Mm (1)
Potent, selective inhibitor of Rho-associated kinase II (ROCK-II). (1)
Potently blocks spleen tyrosine kinase activity. (1)
Selective and potent inhibitor of Cdk2. (1)
Small-molecule receptor tyrosine kinase inhibitor (1)
ssociation of its regulatory chains. (1)
subfamily, and has two isoforms, alpha and beta, that become active upon homodimerization and cgmp binding. (1)
tgf-beta signals through two receptor tyrosine kinases, tgf-betari and tgf-betarii, SD 208 blocks both autocrine and paracrine tgf-beta signaling in glioma cells, inhibiting tgf-beta-induced migration and invasion without affecting viability or proliferati (1)
the sequence corresponds to the mutated s32a phosphorylation site analog within residues 29-35 of human histone h2b, cGKI Kinase Inhibitor Peptide is a synthetic inhibitor of the cgki protein kinase, the cgki kinase belongs to the agc ser/thr family, cgmp (1)
tor and non-receptor tyrosine kinases, vegfr2 kinase inhibitor ii blocks the growth of human umbilical vein endothelial cells stimulated with either vegf or pdgf (ic50 s = 110 nm and 2 µm, respectively). vascular endothelial growth factor receptor 2 (vegfr (1)
Tyr-Specific Protein Kinase Inhibitor Peptide is an inhibitor for tyrosine protein kinases such as egfr and src subfamily members (ic50 = 7.5 mm for pp60 v-src). (1)
vegfr2 kinase inhibitor ii is a reversible, cell-permeable inhibitor of vegfr2's kinase activity (ic50 = 70 nm), VEGFR2 Kinase Inhibitor II less potently inhibits the platelet-derived growth factor receptor beta (pdgfrbeta, ic50 = 920 nm) and related recep (1)
Appearance
a crystalline solid (66)
a lyophilized powder (1)
a solid (1)
a solution in ethanol (1)
a solution in methanol (1)
Crystalline solid. (1)
Lyophilized solids (4)
Off-white solid. (1)
Orange solid. (1)
Pale Yellow Solid (1)
Solid. (3)
White lyophilised solid (1)
White Solid (1)
Yellow Solid (1)
Purity
99.51% (1)
Greater than 90% (1)
Greater than 90% by NMR (2)
Greater than 94% (1)
Greater than 95% (28)
Greater than 95% by HPLC (7)
Greater than 97 % by HPLC (1)
Greater than 97% (1)
Greater than 97% by HPLC (1)
Greater than 97% by HPLC by sum of two isomers (1)
Greater than 98% (43)
Greater than 98% by HPLC (2)
Publications
No (89)
Biological Function
Publications
Showing 1-25 of 89 results for kinase inhibitor

Syk Inhibitor - LS-H4382
622387-85-3
Chemical, Inhibitor
6419747
C18H15N3O3S
Orange solid. / Greater than 97% by HPLC by sum of two isomers
Potent and reversible Syk inhibitor
5mg  $240.00; 1mg  $90.00
17-AAG: A Hsp90 inhibitor

IRAK-1/4 Inhibitor - LS-H3605
509093-47-4
Chemical, Inhibitor
11983295
C20H21N5O
Yellow Solid / Greater than 98% by HPLC
Inhibitor of interleukin-1 receptor associated kinase (IRAK)
5mg  $155.00; 25mg  $520.00
StemBoost™ Reprogramming Cocktail Set I (1000X), Sterile-Filtered: A useful reprogramming cocktail

PI 3-Kinase Inhibitor Set - LS-H2159
Chemical, Inhibitor
Lyophilized solids / Greater than 95% by HPLC
5ea  $460.00

EGFR Tyrosine Kinase Inhibitor Set - LS-H2161
Chemical, Inhibitor
Lyophilized solids / Greater than 95% by HPLC
5ea  $455.00

Receptor Tyrosine Kinase (RTK) Inhibitor Set - LS-H2162
Chemical, Inhibitor
Lyophilized solids / Greater than 95% by HPLC
8ea  $695.00

PathwayReady(tm) MAP Kinase Signaling Inhibitor Panel - LS-H2163
Chemical, Inhibitor
Lyophilized solids / Greater than 95% by HPLC
7ea  $570.00

Apatinib (Free base) - LS-H4150
811803-05-1
Chemical
45139106
C24H23N5O
Solid. / Greater than 98% by HPLC
Small-molecule receptor tyrosine kinase inhibitor
25mg  $360.00; 5mg  $105.00
Apatinib (Free base): Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities

Regorafenib monohydrate - LS-H4156
1019206-88-2
Chemical
24768591
C21H17ClF4N4O4
Solid. / 99.51%
Multi-targeted inhibitor tyrosine kinase
5mg  $105.00; 25mg  $360.00
Regorafenib monohydrate: Regorafenib monohydrate is a multi-targeted inhibitor tyrosine kinase

VEGFR2 Kinase Inhibitor I - LS-H92
15966-93-5
Chemical, Inhibitor
C18H18N2O3
Greater than 94%
A potent, cell-permeable inhibitor of VEGFR2.
500µg  $70.00; 1mg  $115.00; 5mg  $465.00; 10mg  $795.00
LSBio image for Biochemical

IKK-e Kinase Inhibitor II - LS-H2483
862812-98-4
Chemical, Inhibitor
11626927
C22H19N3O5S2
Crystalline solid. / Greater than 97 % by HPLC
IKK-e kinase inhibitor
5mg  $420.00; 1mg  $130.00
IKK-e Kinase Inhibitor II: An IKK-e kinase inhibitor

Sphingosine Kinase Inhibitor, SKI-I - LS-H2667
306301-68-8
Chemical, Inhibitor
C25H18N4O2
Pale Yellow Solid / Greater than 90% by NMR
Non-lipid pan-sphingosine kinase (SK) inhibitor
5mg  $180.00; 25mg  $610.00
GANT58: A Hedgehog (Hh) signaling pathway inhibitor

Sphingosine Kinase Inhibitor, SKI-II - LS-H2668
312636-16-1
Chemical, Inhibitor
753704
C15H11ClN2OS
Off-white solid. / Greater than 90% by NMR
Non-lipid pan-sphingosine kinase (SK) inhibitor
5mg  $170.00; 25mg  $605.00
GANT58: A Hedgehog (Hh) signaling pathway inhibitor

Tyr-Specific Protein Kinase Inhibitor Peptide - LS-H5307
C111H168N30O33
Greater than 95% by HPLC
Tyr-Specific Protein Kinase Inhibitor Peptide is an inhibitor for tyrosine protein kinases such as egfr and src subfamily members (ic50 = 7.5 mm for pp60 v-src).
1mg  $245.00

PKA Inhibitor [6-22] Peptide - LS-H5044
C80H130N28O24
Greater than 95% by HPLC
PKA Inhibitor [6-22] Peptide is a potent and competitive inhibitor of protein kinase a (pka) with a ki = 1.7 nm, PKA Inhibitor [6-22] Peptide is amidated at the c-terminus end, pki-alpha interacts with the catalytic subunit of pka after the camp-induced dissociation of its regulatory chains.
1mg  $180.00

cGKI Kinase Inhibitor Peptide - LS-H5344
C38H74N18O10
Greater than 95% by HPLC
the sequence corresponds to the mutated s32a phosphorylation site analog within residues 29-35 of human histone h2b, cGKI Kinase Inhibitor Peptide is a synthetic inhibitor of the cgki protein kinase, the cgki kinase belongs to the agc ser/thr family, cgmp subfamily, and has two isoforms, alpha and beta, that become active upon homodimerization and cgmp binding.
1mg  $90.00

ERK Inhibitor - LS-H7698
1049738-54-6
Chemical
C14H16N2O3S • HCl
a crystalline solid / Greater than 95%
An ERK inhibitor.
1mg  $55.00; 5mg  $115.00; 500µg  $40.00
LSBio image for Biochemical

JNJ-7706621 - LS-H8300
443797-96-4
Chemical
C15H12F2N6O3S
a crystalline solid / Greater than 98%
A dual inhibitor of CDKs and Aurora kinases.
1mg  $50.00; 10mg  $310.00; 5mg  $185.00
LSBio image for Biochemical

JNK Inhibitor V - LS-H8301
345987-15-7
Chemical
C20H16N6S
a crystalline solid / Greater than 98%
A potent JNK inhibitor used in cells and animals.
10mg  $245.00; 25mg  $465.00; 5mg  $145.00
LSBio image for Biochemical

JNK Inhibitor VIII - LS-H8302
894804-07-0
Chemical
C18H20N4O4
a crystalline solid / Greater than 98%
A non-selective JNK inhibitor.
1mg  $60.00; 10mg  $230.00; 5mg  $150.00
LSBio image for Biochemical

JNK Inhibitor IX - LS-H8303
312917-14-9
Chemical
C20H16N2OS
a crystalline solid / Greater than 98%
A selective inhibitor of JNK2 and JNK3.
10mg  $110.00; 25mg  $210.00; 50mg  $370.00
LSBio image for Biochemical

JNK Inhibitor XVI - LS-H8304
1410880-22-6
Chemical
C29H29N7O2
a crystalline solid / Greater than 95%
A selective, irreversible JNK inhibitor.
10mg  $250.00; 25mg  $445.00; 5mg  $150.00
LSBio image for Biochemical

JAK2 Inhibitor V - LS-H8282
195371-52-9
Chemical
C23H24N2O
a solution in ethanol / Greater than 95%
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK.
10mg  $125.00; 25mg  $245.00; 5mg  $75.00
LSBio image for Biochemical

JX-401 - LS-H8312
349087-34-9
Chemical
C21H25NO2S
a crystalline solid / Greater than 95%
A potent, reversible inhibitor of p38a MAPK.
10mg  $185.00; 5mg  $110.00; 50mg  $700.00
LSBio image for Biochemical

JAK Inhibitor I - LS-H8279
457081-03-7
Chemical
C18H16FN3O
a crystalline solid / Greater than 98%
A pan-JAK inhibitor.
1mg  $165.00; 10mg  $520.00; 5mg  $335.00; 500µg  $110.00
LSBio image for Biochemical

SU 5416 - LS-H91
204005-46-9
Chemical, Inhibitor
C15H14N2O
Greater than 97%
A tyrosine kinase inhibitor.
5mg  $85.00; 10mg  $115.00; 25mg  $250.00; 50mg  $450.00
LSBio image for Biochemical
Showing 1-25 of 89 results for kinase inhibitor

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