Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
The ED50 range is 0.01-0.05 ng/ml, as determined by the dose-dependent secretion of IFN-? from PHA and IL-12 activated mouse splenocytes that has been co-stimulated with PMA. Optimal concentration for individual application should be determined by a dose response assay.
Less than 0.1 ng/µg of protein.
Reconstitute in water to 0.1-0.5 mg/ml, gently pipetting to dissolve. The solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.