Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
GALC Protein, Galactocerebrosidase Protein, GALCERase Protein, Galactosylceramidase Protein, Galactosylceraminidase Protein
Galactocerebrosidase (GALC) is a lysosomal enzyme that hydrolyzes several galactolipids. GALC deficiency is associated with Krabbe disease (globoid cell leukodystrophy). The gene is about 60 kb in length and consists of 17 exons. This gene contains ten GC-box-like sequences within the promoter region but no typical TATA box. This feature is also characteristic of other lysosomal protein encoding genes.