Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DIO2 Protein, 5DII Protein, D2 Protein, DIOII Protein, ITDI2 Protein, Type 2 DI Protein, TXDI2 Protein, Type-II 5-deiodinase Protein, SelY Protein, Type-II 5deiodinase Protein, Thyroxine deiodinase, type II Protein
Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). Thyroid hormone appears to have important regulatory effects in some mammalian tissues, such as the developing brain, the anterior pituitary gland, and brown adipose tissue. A relatively high proportion of the receptor-bound triiodothyronine is found within the tissue itself rather than in plasma.