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PAPPA Protein, DIPLA1 Protein, IGF-dependent IGFBP-4 protease Protein, PAPPA1 Protein, PAPA Protein, PAPP-A Protein, Pappalysin-1 Protein, ASBABP2 Protein, IGFBP-4ase Protein
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.