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Mouse TNFSF18 / GITRL Recombinant (FLAG) Protein LS-G3721


Wt. Vol. Conc. Price
50 µg - - $405
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

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Human TNFSF18 / GITRL Recombinant (6His,C-terminus) Protein - LS-G39874
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Recombinant Protein
~22kDa (SDS-PAGE)
The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
aa 45-173
HEK 293 Cells
Greater than 90% by SDS-PAGE
Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
Less than 0.1 EU/µg protein (determined by LAL method).
10 mM Glycine, pH 10.0
Store at +4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid repeat freeze-thaw cycles.
For research use only.


Q9UNG2 NM_005092 NP_005083.2

TNFSF18 Protein, AITR ligand Protein, AITRL Protein, GITR ligand Protein, GITRL Protein, HGITRL Protein, TL6 Protein

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions.

Functional Assay

Functional Assay
GITRL, Soluble (mouse) (rec.) induced GITR-mediated NF-kappaB activation. HEK293 cells were transiently transfected with 20ng of a (NF-kappaB)-Luc reporter, 2ng of a Renilla luciferase, and with 20ng of a GITR full length encoding construct. At 24 hours after transfection, the indicated amounts of GITRL, Soluble (mouse) (rec.) or a FLAG control protein were treated for 4 hours and followed by the measurement of dual luciferase activities.

Requested From: United States
Date Requested: 10/25/2016

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