Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
PDCD1 / CD279 / PD-1
17.4 kDa. DTT-reduced protein migrates as 25-45 kDa in SDS-PAGE due to glycosylation
HEK 293 Cells
Greater than 95% by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized mouse PDCD1 Protein at 5 µg/ml can bind mouse PDL1 protein Fc Chimera with a linear range of 0.2-5 µg/ml when detected by HRP*-labeled Goat anti Human IgG, Fc? Fragment Mab.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from PBS, pH 7.4, mannitol or trehalose
Centrifuge vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
PDCD1 Protein, CD279 Protein, HPD-1 Protein, HPD-l Protein, PD1 Protein, Protein PD-1 Protein, SLEB2 Protein, PD-1 Protein, CD279 antigen Protein, Programmed cell death 1 Protein
PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.