Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MST1R Protein, C-met-related tyrosine kinase Protein, CD136 Protein, CDw136 Protein, CD136 antigen Protein, Friend virus susceptibility 2 Protein, Fv2 Protein, MSP receptor Protein, p185-Ron Protein, PTK8 protein tyrosine kinase 8 Protein, RON Protein, Soluble RON variant 3 Protein, Soluble RON variant 1 Protein, MST1R variant RON30 Protein, Oncogene RON Protein, PTK8 Protein, MST1R variant RON62 Protein, Protein-tyrosine kinase 8 Protein, RON variant E2E3 Protein, Soluble RON variant 2 Protein, Soluble RON variant 4 Protein
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1.