Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg.
Tris buffer, 50% glycerol.
Reconstitute in sterile distilled water to 0.1-1 mg/ml.
Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
IL36B Protein, FIL1 Protein, FIL1 eta Protein, FILI-(ETA) Protein, IL-1 eta Protein, IL-1F8 Protein, Interleukin 1, eta Protein, Interleukin-1 eta Protein, IL1F8 Protein, Interleukin 36, beta Protein, Interleukin-1 family member 8 Protein, Interleukin-1 Superfamily e Protein, Family of interleukin 1-eta Protein, FIL1H Protein, Interleukin-1 homolog 2 Protein, FIL1-(ETA) Protein, IL-1F8 (FIL1-eta) Protein, IL-1H2 Protein, IL1-ETA Protein, IL1H2 Protein, Interleukin-36 beta Protein
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.