Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Activity of GZMB was tested using the synthetic peptide, IETD-AFC, as a substrate. GZMB releases AFC and then the GZMB activity can be quantified by fluorescent detection of free AFC at Ex/Em = 380/500 nm.
Reconstitute in sterile water to 0.1 µg/µl.
Store at -70°C. Aliquot to avoid freeze/thaw cycles.
GZMB Protein, CCPI Protein, CGL-1 Protein, Cathepsin G-like 1 Protein, CSP-B Protein, CTLA-1 Protein, CTLA1 Protein, CGL1 Protein, CSPB Protein, Fragmentin 2 Protein, GRB Protein, HLP Protein, Human lymphocyte protein Protein, Fragmentin-2 Protein, SECT Protein, Lymphocyte protease Protein, T-cell serine protease 1-3E Protein, C11 Protein, CTSGL1 Protein, Cytotoxic serine protease B Protein, Granzyme B Protein, Granzyme-2 Protein
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.