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Mouse FGF23 Recombinant (Human IgG1 Fc) Protein LS-G3815

Ordering

Wt. Vol. Conc. Price
10 µg - - $275
50 µg - - $415
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular FGF23 Proteins

Human FGF23 Recombinant Protein - LS-G16606
E. coli Expression System
None
Unpurified
Human FGF23 Recombinant (His) Protein - LS-G16612
E. coli Expression System
His
Unpurified
Rat FGF23 Recombinant (His) Protein - LS-G20738
E. coli Expression System
His
Unpurified / Lyophilized

100% Guaranteed 100% Guaranteed
LS-G3815
Recombinant Protein
FGF23
Mouse
~50kDa (SDS-PAGE, full-length) FGF23 is cleaved between arg179 and ser 180 (~40kDa).
Signal peptide and mouse FGF-23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG1.
aa 1-251
HEK 293 Cells
Human
Human IgG1 Fc
Greater than 90% by SDS-PAGE
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Less than 0.1 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Store at +4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid repeat freeze-thaw cycles.
For research use only.

About FGF23

Q9GZV9 NM_020638 NP_065689.1

FGF23 Protein, ADHR Protein, Fibroblast growth factor 23 Protein, FGF-23 Protein, HYPF Protein, Phosphatonin Protein, PHPTC Protein, HPDR2 Protein

FGF23 is a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR).

Functional Assay

Functional Assay
ERK and FRS2alpha phosphorylation induced by FGF-23 in Klotho expressing cells. Klotho expressing HEK 293EBNA cells were serum starved for 16 hours and then stimulated with mFGF-23-Fc (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: Mock (non-treated) Lane 2: Klotho + mFGF23-Fc 1ng/ml Lane 3: Klotho + mFGF23-Fc 10ng/ml Lane 4: Klotho + mFGF23-Fc 100ng/ml Lane 5: Klotho + mFGF23-Fc 500ng/ml Lane 6: Klotho + mFGF23-Fc 1000ng/ml Lane 7: Klotho + 100ng/ml FGF-b
 

Requested From: United States
Date Requested: 12/9/2016

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