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Mouse DLK1 / Pref-1 Recombinant (Human IgG1 Fc) Protein LS-G3800


Wt. Vol. Conc. Price
10 µg - - $325
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

Most Popular DLK1 / Pref-1 Proteins

Human DLK1 / Pref-1 Recombinant (His) Protein - LS-G20670
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Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human DLK1 / Pref-1 Recombinant (6His,C-terminus) Protein - LS-G38971
Human Human Cells

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Recombinant Protein
DLK1 / Pref-1
~75kDa (SDS-PAGE)
Signal peptide and extracellular domain of mouse DLK1 (aa 1-305) are fused at the C-terminus to the Fc portion of human IgG1.
aa 1-305
HEK 293 Cells
Human IgG1 Fc
Greater than 95% by SDS-PAGE
Inhibits adipogenesis of 3T3L-1 cells. Induces Sox-9 in 3T3L-1 cells.
Less than 0.1 EU/µg protein (determined by LAL method).
Lyophilized from PBS, 0.02% CHAPS
Reconstitute with 100 µl sterile water.
Store lyophilized at -20°C for at least 6 months. Once reconstituted store at +4°C for immediate use.
For research use only.

About DLK1 / Pref-1

P80370 NM_003836 NP_003827.3

DLK1 Protein, Delta-like protein dlk Protein, DLK-1 Protein, Delta1 Protein, FA1 Protein, Dlk Protein, Preadipocyte factor 1 Protein, Pref-1 Protein, Protein delta homolog 1 Protein, PG2 Protein, ZOG Protein, Fetal antigen 1 Protein, PREF1 Protein, Secredeltin Protein

DLK1 / Pref-1 is a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele.

Functional Assay

Functional Assay
Induction of Sox-9 with the treatment of DLK1 (mouse):Fc (human) (rec.) (Prod. No. AG-40A-0107Y).Method: A mouse preadipocyte cell line, 3T3L-1, was stimulated with 5 ug/ml of mouse DLK1:Fc as shown in indicated time points and each cell lysate was prepared and subjected to western blot by using an anti-Sox-9 and anti-GAPDH antibody.

Functional Assay

Functional Assay
Adipogenesis inhibition. Macroscopic pictures.

Functional Assay

Functional Assay
Adipogenesis inhibition of 3T3L-1 cells using DLK1 (mouse):Fc (human) (rec.) dissolved in DPBS was added to the differentiation medium. Plates were then used to differentiate 3T3L-1 cells.

Requested From: United States
Date Requested: 10/25/2016

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