Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DLK1 Protein, Delta-like protein dlk Protein, DLK-1 Protein, Delta1 Protein, FA1 Protein, Dlk Protein, Preadipocyte factor 1 Protein, Pref-1 Protein, Protein delta homolog 1 Protein, PG2 Protein, ZOG Protein, Fetal antigen 1 Protein, PREF1 Protein, Secredeltin Protein
DLK1 / Pref-1 is a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele.
Induction of Sox-9 with the treatment of DLK1 (mouse):Fc (human) (rec.) (Prod. No. AG-40A-0107Y).Method: A mouse preadipocyte cell line, 3T3L-1, was stimulated with 5 ug/ml of mouse DLK1:Fc as shown in indicated time points and each cell lysate was prepared and subjected to western blot by using an anti-Sox-9 and anti-GAPDH antibody.
Adipogenesis inhibition. Macroscopic pictures.
Adipogenesis inhibition of 3T3L-1 cells using DLK1 (mouse):Fc (human) (rec.) dissolved in DPBS was added to the differentiation medium. Plates were then used to differentiate 3T3L-1 cells.