Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
The utrophin protein accumulates at neuromuscular synapses and myotendinous junctions. Similarly to dystrophin, utrophin associates with the sarcolemmal dystroglycan complex and anchors the cytoskeleton protein to agrin and laminin in the plasma membrane. Duchenne Muscular Dystrophy (DMD), a disease caused by mutations of the dystrophin gene, is a severe progressive muscle-degenerative disorder that results in premature death.