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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
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Human TNFRSF4 / CD134 / OX40 Protein (Recombinant Fc,C-terminus) (Leu29-Ala216) - LS-G40114
Recombinant Human OX40 is produced by our Mammalian expression system and the target gene encoding Leu29-Ala216 is expressed with a Fc tag at the C-terminus.
Leu29-Ala216
LHCVGDTYPS
NDRCCHECRP
GNGMVSRCSR
SQNTVCRPCG
PGFYNDVVSS
KPCKPCTWCN
LRSGSERKQL
CTATQDTVCR
CRAGTQPLDS
YKPGVDCAPC
PPGHFSPGDN
QACKPWTNCT
LAGKHTLQPA
SNSSDAICED
RDPPATQPQE
TQGPPARPIT
VQPTEAWPRT
SQGPSTRPVE
VPGGRAVAIE
GRMDPKSCDK
THTCPPCPAP
ELLGGPSVFL
FPPKPKDTLM
ISRTPEVTCV
VVDVSHEDPE
VKFNWYVDGV
EVHNAKTKPR
EEQYNSTYRV
VSVLTVLHQD
WLNGKEYKCK
VSNKALPAPI
EKTISKAKGQ
PREPQVYTLP
PSRDELTKNQ
VSLTCLVKGF
YPSDIAVEWE
SNGQPENNYK
TTPPVLDSDG
SFFLYSKLTV
DKSRWQQGNV
FSCSVMHEAL
HNHYTQKSLS
LSPGK
Human Cells
Human
Fc,C-terminus
Greater than 95% by SDS-PAGE
Not Tested
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from 0.2 µm filtered PBS, pH 7.4.
Lyophilized protein should be stored at less than -20°C. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at less than -20°C for 3 months.
TNFRSF4 / CD134 / OX40 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis.
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