Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
The ED50 as determined by the ability of TGF-ß2 to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is <0.2 ng/ml, corresponding to a specific activity of > 5 x 106 units/mg.
Less than 0.1 ng/µg of protein.
Reconstitute in 1 mM Citrate buffer, pH 3.5, to 100-1000 ug/ml. The solution can then be stored at 4°C for 1 month. It is recommended that further dilutions be made into PBS containing 2 mg/ml albumin and stored at -20°C.
TGFB2 / TGF Beta2 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers.