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Human SIRT7 / Sirtuin 7 Recombinant (His) Protein (aa1-400) - LS-G3827


Wt. Vol. Conc. Price
10 µg - - Unavailable
50 µg - - Unavailable

Most Popular SIRT7 / Sirtuin 7 Proteins

Human SIRT7 / Sirtuin 7 Recombinant (His) Protein (aa1-400) - LS-G3827
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Functional Assay Image
Human SIRT7 / Sirtuin 7 Recombinant (His) Protein - LS-G5398
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Rat SIRT7 / Sirtuin 7 Recombinant (His) Protein (aa275-397) - LS-G15592
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100% Guaranteed 100% Guaranteed
Recombinant Protein
SIRT7 / Sirtuin 7
~45kDa (SDS-PAGE)
Human sirtuin 7 (aa 1-400) is fused at the N-terminus to a His-tag.
aa 1-400
E. coli
E. coli
Greater than 90% by SDS-PAGE
HDAC activity.
Lyophilized from PBS.
Store at +4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid repeat freeze-thaw cycles.
For research use only.

About SIRT7 / Sirtuin 7

Q9NRC8 NM_016538 NP_057622.1

SIRT7 Protein, SIR2L7 Protein, Sirtuin type 7 Protein, SIR2-like protein 7 Protein, Sir2-related protein type 7 Protein, Sirtuin 7 Protein

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor.

Functional Assay

Functional Assay
HDAC activity (HDAC Fluorimetric Assay -AK-500 from ELS). This assay is performed in two stages. In the first stage, the HDAC(s) acts on the Substrate (10 uM, 50 uM) (total volume of 50 ul). The second stage, is initiated by the addition of 50 ul of developer, stops HDAC activity and produces the fluorescent signal. The samples are read in a microplate reading fluorimeter, capable of excitation at a wavelength in the range 350~380nm and detection of emission light in the range 440~460nm.

Requested From: 
Date Requested: 3/29/2017

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