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Human SIRT2 / Sirtuin 2 Recombinant (His) Protein LS-G3811


Wt. Vol. Conc. Price
10 µg - - $275
50 µg - - $385
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

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Human SIRT2 / Sirtuin 2 Recombinant (His) Protein - LS-G18578
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100% Guaranteed 100% Guaranteed
Recombinant Protein
SIRT2 / Sirtuin 2
~45kDa (SDS-PAGE)
Human sirtuin 2 (aa 2-389) is fused at the N-terminus to a His-tag.
aa 2-389
E. coli
E. coli
Greater than 90% by SDS-PAGE
HDAC activity.
Less than 1.0 EU/µg protein (determined by LAL method).
50 mM Tris-HCl, pH 8.2, 100 mM NaCl
Store at +4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid repeat freeze-thaw cycles.
For research use only.

About SIRT2 / Sirtuin 2

Q8IXJ6 NM_030593 NP_085096.1

SIRT2 Protein, SIR2 Protein, Sir2-related protein type 2 Protein, SIR2L Protein, SIR2L2 Protein, Sirtuin 2 Protein, Silent information regulator 2 Protein, SIR2-like protein 2 Protein, Sirtuin type 2 Protein

NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability.

Functional Assay

Functional Assay
HDAC activity (HDAC Fluorimetric Assay -AK-500 from ELS). This assay is performed in two stages. In the first stage, the HDAC(s) acts on the Substrate (10 uM, 50 uM) (total volume of 50 ul). The second stage, is initiated by the addition of 50 ul of developer, stops HDAC activity and produces the fluorescent signal. The samples are read in a microplate reading fluorimeter, capable of excitation at a wavelength in the range 350~380nm and detection of emission light in the range 440~460nm.

Functional Assay

Functional Assay
Inhibition of Sirtuin2 activity by nicotinamide. Substrate: flour de Lys, 50 uM, NAD+ : 200 uM.

Requested From: United States
Date Requested: 10/26/2016

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