Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Constitutively active human plasminogen activator inhibitor 1, stable mutant 14-1B having a Molecular mass of 43 kDa. This human form of SERPINE1 contains the following four mutations: K154T, Q139L, M354I and N150H. These mutations combine to confer great stability to the otherwise labile molecule essentially locking it into the active conformation. The SERPINE1 is purified by proprietary chromatographic techniques.
Greater than 95% by SDS-PAGE and HPLC
50 mM sodium phosphate, pH 6.6, 100 mM NaCl, 1 mM EDTA
SERPINE1 / PAI-1 is a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.