Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
PVRL2 / CD112
Met 1-Gly 351
HEK 293 Cells
Greater than 98% by SDS-PAGE
Measured by its binding ability in a functional ELISA. 1. Immobilized mouse CD112-His at 10 µg/ml (100 µl/well) can bind biotinylated mouse DNAM1-His with a linear range of 0.156-5.0 µg/ml. 2. Immobilized mouse CD112-His at 10 µg/ml (100 µl/well) can bind mouse DNAM1-Fc with a linear range of 0.03-1.0 µg/ml.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from sterile PBS, pH 7.4
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
PVRL2 Protein, HVEB Protein, Herpesvirus entry protein B Protein, Poliovirus receptor-like 2 Protein, Nectin-2 Protein, PRR2 Protein, PVRR2 Protein, CD112 Protein, CD112 antigen Protein, Herpes virus entry mediator B Protein, Herpesvirus entry mediator B Protein
PVRL2 / CD112 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis.