Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Specific activity: >8,000 units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme hydrolyzing 1 nmole of p-nitrophenyl phosphate (pNPP) per minute at 37C, pH7.5 using 10 mM of substrate.
Less than 1.0 EU/µg protein (determined by LAL method).
10 mM Tris-HCl, pH 7.5, 50 mM NaCl, 1 mM MnCl2, 20% glycerol, 2 mM DTT
PPM1A Protein, PP2Calpha Protein, Protein phosphatase 1A Protein, Protein phosphatase 2C alpha Protein, Protein phosphatase IA Protein, PP2CA Protein, PPPM1A Protein, PP2C-ALPHA Protein
PPM1A / PP2CA is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses.