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Human PIK3CG / PI3K Gamma Recombinant (GST) Protein - LS-G18510


Wt. Vol. Conc. Price
1 µg - - Unavailable
5 µg - - Unavailable
10 µg - - Unavailable

Most Popular PIK3CG / PI3K Gamma Proteins

Human PIK3CG / PI3K Gamma Recombinant (His) Protein - LS-G18509
Insect Sf9 Cells
Unpurified / Lyophilized
Human PIK3CG / PI3K Gamma Recombinant (GST) Protein - LS-G18510
Insect Sf9 Cells
Unpurified / Lyophilized
Human PIK3CG / PI3K Gamma Recombinant (His) Protein - LS-G18511
Insect Sf9 Cells
Unpurified / Lyophilized

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Recombinant Protein
PIK3CG / PI3K Gamma
The class IA PI3K? is expressed in endothelial and in white blood cells. Recently it was shown that the inactivation of PI3K? in bone marrow mast cells (BBMCs) leads to defective stem cell factor-mediated proliferation, adhesion and migration of these cells, and to impaired allergen-IgE induced degranulation and cytokine release. In neutrophils a role for PI3K? in TNFa-induced signaling was demonstrated by a reduction in Aktphosphorylation and PDK1 activity upon treatment with the d-specific inhibitor IC87114. The catalytic subunit carries a GST-Tag which facilitates the protein?€™s application in typical GST pull-down assays and the heterodimer was purified by affinity chromatography. The molecular weight for p110? chain is 120.2 kDa (without Tag) and the p85? chain 83.5 kDa.
Sf9 Cells
Greater than 95% by SDS-PAGE
25 mM Tris-HCl, pH 8.0, 25 mM NaCl, 25 mM MgCl2, 50% glycerol.
Store at -20°C. Avoid freeze/thaw cycles.
For research use only.

About PIK3CG / PI3K Gamma

P48736 NM_002649 NP_002640.2

PIK3CG Protein, p110-gamma Protein, p110gamma Protein, PI3-kinase subunit gamma Protein, PI3K Protein, PIK3 Protein, p120-PI3K Protein, PI3CG Protein, PI3K-gamma Protein, PI3Kgamma Protein, PtdIns-3-kinase subunit gamma Protein

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production.

Requested From: 
Date Requested: 3/30/2017

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