Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
PDIA3 Protein, 58 kDa microsomal protein Protein, ER protein 57 Protein, ERp60 Protein, ERp61 Protein, Disulfide isomerase ER-60 Protein, Endoplasmic reticulum P58 Protein, GRP58 Protein, HsT17083 Protein, p58 Protein, Phospholipase C-alpha Protein, PI-PLC Protein, ER protein 60 Protein, ER60 Protein, ERp57 Protein, GRP57 Protein, Protein disulfide-isomerase A3 Protein
PDIA3 / ERp57 encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.