Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SHC1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 494 amino acids (1-474) and having a molecular mass of 53.8 kDa.The SHC1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Greater than 90% by SDS-PAGE
20 mM Tris-HCl, pH 8, 20 mM DTT, 20 mM NaCl, 20 mM PMSF, 20% glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
SHC1 Protein, p46 shc Protein, p52 shc Protein, SH2 domain protein C1 Protein, p66 Protein, SHCA Protein, SHC Protein, SHC-transforming protein 1 Protein, SHC-transforming protein 3 Protein, SHC-transforming protein A Protein
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.