Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
NR1H4 Protein, BAR Protein, Farnesyl x receptor Protein, FXR Protein, HRR1 Protein, Farnesoid x activated receptor Protein, Farnesoid X receptor Protein, Farnesol receptor HRR-1 Protein, HRR-1 Protein, RXR-interacting protein 14 Protein, RIP14 Protein, Bile acid receptor Protein, Farnesoid X nuclear receptor Protein, Farnesoid X-activated receptor Protein
Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol.