Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MSH6 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 51 amino acids (350-400 a.a.) having a total Mw of 33 kDa. Human MSH6 is fused to a GST tag and purified by proprietary chromatographic techniques.
50 mM Tris-HCl, pH 7.5, 50 mM L-glutathione (reduced).
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
MSH6 Protein, GTBP Protein, HSAP Protein, GTMBP Protein, MutS (E. coli) homolog 6 Protein, HMSH6 Protein, Sperm-associated protein Protein, p160 Protein, G/T mismatch-binding protein Protein, HNPCC5 Protein, MutS homolog 6 (E. coli) Protein, MutS-alpha 160 kDa subunit Protein
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.