Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MMP-2 activity was measured by its ability to cleave a chromogenic peptide MMP-2 substrate at room temperature. At an MMP2 concentration of 2.5 g/ml, 50% cleavage was achieved at an incubation time of approximately 25 mins.
Sodium phosphate, calcium chloride
Prior to reconstitution store at 4°C. Once reconstituted, store at -20°C. Store undiluted. Avoid freeze/thaw cycles.
MMP2 Protein, 72 kd type iv collagenase Protein, 72 kDa gelatinase Protein, 72 kd gelatinase Protein, 72 kDa type IV collagenase Protein, CLG4A Protein, CLG4 Protein, GelA Protein, Gelatinase A Protein, Matrix metalloproteinase-2 Protein, MMP-2 Protein, MONA Protein, Neutrophil gelatinase Protein, TBE-1 Protein, Tbe-1 metalloprotease Protein, Collagenase type IV-A Protein, Matrix metalloproteinase-II Protein, MMP-II Protein
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways.