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Human LAG3 Recombinant (Human IgG1 Fc) Protein LS-G3890


Wt. Vol. Conc. Price
50 µg - - $375
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

Most Popular LAG3 Proteins

Human LAG3 Recombinant (His + GST) Protein - LS-G20913
E. coli Expression System
His + GST
Unpurified / Lyophilized
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human LAG3 Recombinant (6His,C-terminus) Protein - LS-G40049
Human Human Cells
Mouse LAG3 Recombinant (6His,C-terminus) Protein - LS-G40111
Human Human Cells

100% Guaranteed 100% Guaranteed
Recombinant Protein
~80kDa (SDS-PAGE)
The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.
CHO Cells
Human IgG1 Fc
Greater than 99% by SDS-PAGE
Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.
Less than 0.1 EU/µg protein (determined by LAL method).
Store at +4°C for immediate use, or aliquot and store at -20°C for at least 6 months. Avoid repeat freeze-thaw cycles.
For research use only.

About LAG3

P18627 NM_002286 P18627

LAG3 Protein, CD223 antigen Protein, LAG-3 Protein, Protein FDC Protein, CD223 Protein, FDC Protein, Lymphocyte-activation gene 3 Protein

Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Functional Assay

Functional Assay
Binding of LAG-3 (human):Fc (human) (rec.) and EBV-transformed B-cells are incubated with either an anti-MHC class II MAb (10 ug/ml) or LAG-3 (human):Fc (human) (rec.) (10 ug/ml) for 30 minutes. at 4°C in PBS/1% BSA. The cells are then stained for 30 minutes. at 4°C with FITC-labeled goat anti-human Fc antibodies.

Functional Assay

Functional Assay
LAG 3 (human):Fc (human) (rec.)-induced dendritic cells (DC) maturation. Method: Immature DCs derived from human monocytes, resuspended at 1x10^6 cells/ml in complete culture medium, are incubated with LAG-3 (human):Fc (human) (rec.) (10ug/ml), LPS (positive control, 5ug/ml) or human IgG1 (isotype-matched negative control, 10ug/ml) for 48 hours. DC maturation induced by LAG-3 (human):Fc (human) (rec.) binding to MHC class II or LPS is assessed by the increased expression of MHC Class II, CD80, CD83, CD86 and CD40.

Requested From: United States
Date Requested: 10/23/2016

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