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Human JAG1 / Jagged 1 Recombinant (Human IgG1 Fc) Protein LS-G3788

Ordering

Wt. Vol. Conc. Price
10 µg - - $275
50 µg - - $385
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular JAG1 / Jagged 1 Proteins

Mouse JAG1 / Jagged 1 Recombinant (His + T7) Protein - LS-G14301
E. coli Expression System
His + T7
Unpurified
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human JAG1 / Jagged 1 Recombinant (Fc,C-terminus) Protein - LS-G39375
Human Human Cells
Fc,C-terminus
Unpurified

100% Guaranteed 100% Guaranteed
LS-G3788
Recombinant Protein
JAG1 / Jagged 1
Human
~150kDa (SDS-PAGE)
Signal peptide and extracellular domain of human Jagged-1 (HJ1; CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.
HEK 293 Cells
Human
Human IgG1 Fc
Greater than 90% by SDS-PAGE
Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
Less than 0.1 EU/µg protein (determined by LAL method).
PBS.
Store at +4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid repeat freeze-thaw cycles.
For research use only.

About JAG1 / Jagged 1

P78504 NM_000214 NP_000205.1

JAG1 Protein, AGS Protein, AHD Protein, Alagille syndrome Protein, CD339 antigen Protein, HJ1 Protein, Jagged1 Protein, JAGL1 Protein, Jagged Protein, Jagged 1 Protein, Protein jagged-1 Protein, AWS Protein, CD339 Protein, Soluble protein jagged Protein

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).

Functional Assay

Functional Assay
Adipogenesis inhibition of 3T3L-1 cells. 3T3L1 cells were maintained in DMEM supplemented with 10% FBS and penicillin-streptomycin. When the cells were confluently grown adipogenesis was initiated by adding IBMX, Dexamethasone, and insulin to 0.5mM, 1 uM, and 10 ug/ml, respectively and continued for 2 days (day 0). The medium was replaced every 2 days with new medium containing insulin in the presence or absence of 5 ug/ml of human Jagged1-Fc and human CD137-Fc as a control-Fc. Staining with Oil Red O was typically performed on day 7.

Functional Assay

Functional Assay
Adipogenesis inhibition. Macroscopic pictures.

Functional Assay

Functional Assay
Induction of Hes-1 with the treatment of recombinant human Jagged1-Fc (Prod. No. AG-40A-0081). A mouse preadpipocyte cell line, 3T3L1, was stimulated with 5 ug/ml of human Jagged1-Fc as in indicated time points and each cell lysate was prepared and subjected to western blot by using anti-human Hes1 or GAPDH.
 

Requested From: United States
Date Requested: 12/5/2016

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