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| Catalog Number | Size | Price |
|---|---|---|
| LS-G47982-100 | 100 µg | $472 |
| LS-G47982-1 | 1 mg | $2,272 |
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Human IL6R / IL6 Receptor Protein (Recombinant His,C-terminus) (Met1-Pro365) - LS-G47982
Human IL6R / IL6 Receptor Protein (Recombinant His,C-terminus) (Met1-Pro365) - LS-G47982
Description:
IL6R / IL6 Receptor Protein LS-G47982 is a Recombinant Human IL6R / IL6 Receptor produced in HEK 293 Cells Met1-Pro365 of NP_000556.1 with His,C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Description:
IL6R / IL6 Receptor Protein LS-G47982 is a Recombinant Human IL6R / IL6 Receptor produced in HEK 293 Cells Met1-Pro365 of NP_000556.1 with His,C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Specifications
Type
Recombinant Protein
Target
IL6R / IL6 Receptor
Synonyms
IL6R | CD126 | gp80 | IL-6R subunit alpha | IL-6R-alpha | IL-6RA | IL6Q | IL-6 receptor subunit alpha | IL-6R 1 | IL-6R-1 | Interleukin 6 receptor | Membrane glycoprotein 80 | CD126 antigen | IL6RA | IL6RQ
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Applications
- Binding
- ELISA
- Functional Assay
- Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Tag
His,C-terminus
Region
Met1-Pro365 of NP_000556.1
Predicted Molecular Weight
The soluble form of recombinant human IL6R consists of 357 amino acids and has a predicted molecular mass of 40 kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 60-65 kDa due to glycosylation.
Expression System
HEK 293 Cells
Source Species
Human
Purification
> 90 % as determined by SDS-PAGE
Bio-Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL-6 at 8 µg/mL (100µl/well) can bind recombinant human IL6R with a linear range of 1.25-20.0 ng/ml. Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.
Endotoxin
Less than 1.0 EU/µg protein (determined by LAL method).
Presentation
Lyophilized from sterile PBS, pH 7.4, with 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Reconstitution
Reconstitute in 400ul of sterile water to a concentration of 0.25mg/ml
Storage
Aliquot and store at -20°C to -80°C for one year. Avoid repeated freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About IL6R / IL6 Receptor
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Binding
Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) bound Anti-IL6R Antibody was 0.1 nM.
Functional Assay
Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Binding
Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) bound Anti-IL6R Antibody was 0.1 nM.
Functional Assay
Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Binding
Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) bound Anti-IL6R Antibody was 0.1 nM.
Functional Assay
Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Binding
Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) bound Anti-IL6R Antibody was 0.1 nM.
Functional Assay
Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Popular IL6R / IL6 Receptor Proteins
Source:
Hamster-Chinese
Tag:
None
Source:
Hamster-Chinese
Tag:
Mouse IgG2 Fc
Source:
Human
Tag:
Myc-DDK (Flag)
Source:
Hamster-Chinese
Tag:
Human IgG1 Fc
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
