Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Purified / Lyophilized / Biologically Active / Endotoxin Level: Less than 0.1 ng/µg of protein (less than 1EU/µg).
IL36RN / IL1F5
Recombinant Human IL-36RA is produced by our E. coli expression system and the target gene encoding Met1-Asp155 is expressed.
Greater than 95% by SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from 0.2 µm filtered 20 mM Tris-HCl, pH 7.5, 150 mM NaCl.
Lyophilized protein should be stored at less than -20°C. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at less than -20°C for 3 months.
IL36RN Protein, FIL1 Protein, FIL1D Protein, IL-1 delta Protein, IL-1 related protein 3 Protein, IL-1HY1 Protein, IL-1RP3 Protein, IL-1-related protein 3 Protein, IL1F5 Protein, IL1RP3 Protein, IL1L1 Protein, IL36RA Protein, Interleukin-1 delta Protein, Family of interleukin 1-delta Protein, FIL1 delta Protein, IL-1L1 Protein, IL-1ra homolog 1 Protein, Interleukin-1 family member 5 Protein, Interleukin-1-like protein 1 Protein, FIL1(DELTA) Protein, IL-1F5 Protein, IL1HY1 Protein, Interleukin-1 HY1 Protein, PSORP Protein
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation.