Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene.
Binding of IL-2 Superkine (Fc) (AG-40B-0111) to IL-2Rbeta (human) is increased >10 fold compared to IL-2 (human):Fc (human) . Methods: IL-2Rbeta (human) was coated on an ELISA plate at 1 ug/ml. After blocking and washing steps, indicated concentrations of IL-2 Superkine (Fc) or IL-2 (human):Fc (human) were added. Following incubation for 1 h at RT, the binding was detected using an anti-human Fc antibody (HRP).