Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IL1R1 Protein, Antigen CD121a Protein, D2S1473 Protein, IL-1R-1 Protein, IL-1R-alpha Protein, IL-1RT-1 Protein, IL-1RT1 Protein, IL1R Protein, IL1RA Protein, IL1RT1 Protein, Interleukin receptor 1 Protein, Interleukin-1 receptor alpha Protein, Interleukin-1 receptor type 1 Protein, CD121A Protein, CD121a antigen Protein, Interleukin 1 receptor, type I Protein, Interleukin-1 receptor type I Protein, Interleukin-1 type i receptor Protein, p80 Protein
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.