Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
51 kDa. DTT-reduced protein migrates as 66-90 kDa due to glycosylation
HEK 293 Cells
Human IgG1 Fc
Greater than 95% by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized rhIL7Ra Fc Chimera at 0.25 µg/ml (100 µl/well) on a Rabbit anti-human IgG Fc antibody, the concentration of rhIL-7 that produces 50% of the optimal binding response is found to be approximately 20 - 100 ng/mL.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from PBS, pH 7.4, mannitol or trehalose
Centrifuge the vial before opening. Reconstitute in sterile PBS, pH 7.4 to 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, store at -20°C.
IL17RA Protein, CANDF5 Protein, CD217 antigen Protein, CDw217 Protein, CD217 Protein, HIL-17R Protein, IL-17RA Protein, IL17R Protein, Interleukin-17 receptor A Protein, IL-17 receptor Protein, IL-17 receptor A Protein, Interleukin 17 receptor Protein, Interleukin 17 receptor A Protein
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.