Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
1. Measured by its binding ability in a functional ELISA. Immobilized rat IL17RA-His at 10 µg/ml (100 µl/well) can bind biotinylated human IL17A, The EC50 of biotinylated human IL17A is 5-11.8 ng/ml.2.Measured by its binding ability in a functional ELISA. Immobilized mouse IL17a at 10 µg/ml (100 µl/well) can bind rat IL17RA-His, The EC50 of rat IL17RA-His is 0.44-1.02 µg/mL.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from sterile PBS, pH 7.4
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
IL17RA Protein, CANDF5 Protein, CD217 antigen Protein, CDw217 Protein, CD217 Protein, HIL-17R Protein, IL-17RA Protein, IL17R Protein, Interleukin-17 receptor A Protein, IL-17 receptor Protein, IL-17 receptor A Protein, Interleukin 17 receptor Protein, Interleukin 17 receptor A Protein
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.