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Human IL-33 Protein (Recombinant) - LS-G27249

Catalog Size Price
LS-G27249-10 10 µg Unavailable
LS-G27249-50 50 µg Unavailable
LS-G27249-1 1 mg Unavailable

Most Popular IL-33 Proteins

Human IL-33 Protein (Recombinant) - LS-G189
E. coli Expression System
159 AA
Purified / Lyophilized / Biologically Active / Endotoxin Level: Less than 0.1 ng/µg of protein (less than 1EU/µg).
Mouse IL-33 Protein (Recombinant) - LS-G200
E. coli Expression System
158 AA
Purified / Lyophilized / Biologically Active / Endotoxin Level: Less than 0.1 ng/µg of protein (less than 1EU/µg).
Mouse IL-33 Protein (Recombinant His) - LS-G3081
E. coli Expression System
181 AA
Purified / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Mouse IL-33 Protein (Recombinant) - LS-G4338
E. coli Expression System
Purified / Lyophilized / Biologically Active / Endotoxin Level: Less than 0.1 ng/µg of protein.
Human IL-33 Protein (Recombinant) (aa112-270) - LS-G23533
E. coli Expression System
176 AA
Lyophilized / Biologically Active / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).

100% Guaranteed
Recombinant Protein
18.0 kDa (SDS-PAGE)
Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response. Evidence suggests IL-33 plays a role in autoimmune disease. IL-33’s interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus. Recombinant humanInterleukin-33 (rhIL-33) produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhIL-33 has a molecular mass of 18.0 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
E. coli
E. coli
Greater than 95% by SDS-PAGE
ED50 <0.5ng/mL, as determined by a cell proliferation assay using D10S cells, corresponding to a specific activity of > 2x 10^6 units/mg.
Less than 0.2 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.
For research use only.

About IL-33

O95760 NM_033439 NP_254274.1

IL33 Protein, C9orf26 Protein, DVS27 Protein, DVS27-related protein Protein, IL-1F11 Protein, IL-33 Protein, Interleukin-33 Protein, NFEHEV Protein, NF-HEV Protein, Interleukin-1 family member 11 Protein, NFHEV Protein, IL1F11 Protein, Interleukin 33 Protein, RP11-575C20.2 Protein

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells.

Requested From: 
Date Requested: 6/21/2018

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