Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
HSPB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-196 a.a.) and having a molecular mass of 23.7kDa. The HSPB8 is fused to a 20 amino acid His Tag at N-terminus and purified by conventional chromatography.
Greater than 95% by SDS-PAGE
20 mM Tris-HCl, pH 8, 20 mM NaCl, 10% glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
HSPB8 Protein, Alpha-crystallin C chain Protein, CMT2L Protein, Crystallin alpha c Protein, DHMN2 Protein, E2-induced gene 1 protein Protein, CRYAC Protein, E2IG1 Protein, HMN2 Protein, H11 Protein, Heat shock 27kDa protein 8 Protein, Heat shock protein beta-8 Protein, Heat shock 22kDa protein 8 Protein, HMN2A Protein, HSP22 Protein, Protein kinase H11 Protein
HSPB8 / H11 / HSP22 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy.