Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
HMGN1 binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. HMGN1 has been shown to enhance transcription on chromatin templates but not on DNA templates suggesting that the association of HMGN1 with nucleosomes is part of the cellular process involved in the generation of transcriptionally active chromatin. During mitosis HMGN1 is phosphorylated in its chromatin binding domain.