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Human FZD5 / Frizzled 5 Recombinant (Human IgG1 Fc) Protein - LS-G3964


Wt. Vol. Conc. Price
50 µg - - Unavailable

Most Popular FZD5 / Frizzled 5 Proteins

Human FZD5 / Frizzled 5 Recombinant (Human IgG1 Fc) Protein - LS-G3964
Human HEK 293 Cells
Human IgG1 Fc
Unpurified / Endotoxin Level: Less than 0.01 EU/µg protein (determined by LAL method).
Functional Assay Image
Human FZD5 / Frizzled 5 Recombinant (GST) Protein - LS-G31018
Wheat Wheat Germ Extract
Unpurified / Lyophilized
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

100% Guaranteed 100% Guaranteed
Recombinant Protein
FZD5 / Frizzled 5
~50kDa (SDS-PAGE)
The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.
HEK 293 Cells
Human IgG1 Fc
Greater than 95% by SDS-PAGE
Less than 0.01 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Reconstitute with 50 µl sterile water.
Store lyophilized at -20°C for at least 6 months. Once reconstituted store at +4°C for immediate use.
For research use only.

About FZD5 / Frizzled 5

Q13467 NM_003468 NP_003459.2

FZD5 Protein, C2orf31 Protein, DKFZP434E2135 Protein, Frizzled family receptor 5 Protein, Fz5 Protein, Fzd-5 Protein, FzE5 Protein, Frizzled 5 Protein, Frizzled-5 Protein, Wnt receptor Protein, Fz-5 Protein, HFZ5 Protein

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Functional Assay

Functional Assay
Figure: Frizzled-5 (human):Fc (human) (rec.) (AG-40B-0133) efficiently inhibits Wnt3a activation. Methods: Inhibition of Wnt3a activation by Frizzled-5 (human):Fc (human) (rec.) was measured by using HEK293 cells transfected with a plasmid containing a luciferase gene under the control of a Wnt dependent promoter. Firefly luciferase activity was measured after incubation for 18h at 37 degrees C with 0.5ug/ml of Wnt3a with or without Frizzled-5 (h):Fc (concentrations indicated in the Figure). As negative control, medium only and 20ug/ml Frizzled-5 (h):Fc only did not show any signals (not shown). (Experiment performed by Alexey Koval, Prof. Katanaev Lab, University of Lausanne)

Requested From: 
Date Requested: 3/30/2017

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