LSBio The Immunohistochemistry Antibody Company
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA Kits
  • All Kits
  • Sandwich ELISA Kits
  • Competitive EIA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Direct ELISA Kits
  • Functional ELISA Kits
  • Phospho-Specific ELISA Kits
  • Custom ELISA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
  • Other
  • Blocking Peptides
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question?
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Publications
  • Secure Logins
  • Login to Our Secure FTP Site
  • Login to Our IHC Database
Contact Us

2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products. - To submit a new order. - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues. - To request technical information requests about an LSBio product or its application. - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Quick Order ▾
View Cart

Human FZD5 / Frizzled 5 Recombinant (Human IgG1 Fc) Protein LS-G3964


Wt. Vol. Conc. Price
50 µg - - $365
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

Most Popular FZD5 / Frizzled 5 Proteins

Human FZD5 / Frizzled 5 Recombinant (Human IgG1 Fc) Protein - LS-G3964
Human HEK 293 Cells
Human IgG1 Fc
Unpurified / Endotoxin Level: Less than 0.01 EU/µg protein (determined by LAL method).
Functional Assay Image
Human FZD5 / Frizzled 5 Recombinant (GST) Protein - LS-G31018
Wheat Wheat Germ Extract
Unpurified / Lyophilized
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human FZD5 / Frizzled 5 Protein - LS-G48403

100% Guaranteed 100% Guaranteed
Recombinant Protein
FZD5 / Frizzled 5
~50kDa (SDS-PAGE)
The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.
HEK 293 Cells
Human IgG1 Fc
Greater than 95% by SDS-PAGE
Less than 0.01 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Reconstitute with 50 µl sterile water.
Store lyophilized at -20°C for at least 6 months. Once reconstituted store at +4°C for immediate use.
For research use only.

About FZD5 / Frizzled 5

Q13467 NM_003468 NP_003459.2

FZD5 Protein, C2orf31 Protein, DKFZP434E2135 Protein, Frizzled family receptor 5 Protein, Fz5 Protein, Fzd-5 Protein, FzE5 Protein, Frizzled 5 Protein, Frizzled-5 Protein, Wnt receptor Protein, Fz-5 Protein, HFZ5 Protein

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Functional Assay

Functional Assay
Figure: Frizzled-5 (human):Fc (human) (rec.) (AG-40B-0133) efficiently inhibits Wnt3a activation. Methods: Inhibition of Wnt3a activation by Frizzled-5 (human):Fc (human) (rec.) was measured by using HEK293 cells transfected with a plasmid containing a luciferase gene under the control of a Wnt dependent promoter. Firefly luciferase activity was measured after incubation for 18h at 37 degrees C with 0.5ug/ml of Wnt3a with or without Frizzled-5 (h):Fc (concentrations indicated in the Figure). As negative control, medium only and 20ug/ml Frizzled-5 (h):Fc only did not show any signals (not shown). (Experiment performed by Alexey Koval, Prof. Katanaev Lab, University of Lausanne)

Requested From: United States
Date Requested: 10/28/2016

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn
Copyright © 2016 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number