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Human FLT3LG / Flt3 Ligand Recombinant (Human IgG1 Fc) Protein LS-G3949


Wt. Vol. Conc. Price
10 µg - - $305
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

Most Popular FLT3LG / Flt3 Ligand Proteins

Human FLT3LG / Flt3 Ligand Recombinant Protein - LS-G4239
E. coli Expression System
Unpurified / Endotoxin Level: Less than 0.1 ng/µg of protein.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Mouse FLT3LG / Flt3 Ligand Recombinant Protein - LS-G4240
E. coli Expression System
Unpurified / Endotoxin Level: Less than 0.1 ng/µg of protein.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Rhesus monkey FLT3LG / Flt3 Ligand Recombinant Protein - LS-G5864
E. coli Expression System
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

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Recombinant Protein
FLT3LG / Flt3 Ligand
The receptor-binding domain of human FLT3L is fused at the N-terminus to the Fc portion of human IgG1.
CHO Cells
Human IgG1 Fc
Greater than 95% by SDS-PAGE
In vitro and in vivo generation of conventional and plasmacytoid dendritic cells (DC). FLT3L increases in vivo both NK and DC cells numbers in the spleen when mice are injected intraperitoneally with 2 or 10 µg, daily for 10 days (slightly higher effect at 10 µg).
Less than 0.1 EU/µg protein (determined by LAL method).
PBS, sterile.
Store at +4°C for immediate use, or aliquot and store at -20°C for at least 6 months. Avoid repeat freeze-thaw cycles.
For research use only.

About FLT3LG / Flt3 Ligand

P49771 NM_001459 NP_001450.2

FLT3LG Protein, FL Protein, Flt3 ligand Protein, FLT3L Protein, SL cytokine Protein

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).

Functional Assay

Functional Assay
Influence of FLT3L treatment on lymphocyte subpopulations. Method: C57BL/6 mice were injected intraperitoneally with 10 ug daily or were left untreated. (A) Percentages of indicated splenic subpopulations in FLT3L KO, WT control or WT-treated mice. (B) Absolute cell numbers of indicated splenic subpopulations in FLT3L KO, WT control, or WT-treated mice.

Requested From: United States
Date Requested: 10/21/2016

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