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Human FGF21 Recombinant (Human IgG1 Fc) Protein LS-G3795


Wt. Vol. Conc. Price
10 µg - - $275
50 µg - - $415
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)

Most Popular FGF21 Proteins

Mouse FGF21 Recombinant Protein - LS-G4243
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Mouse FGF21 Recombinant (His) Protein - LS-G16956
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Bovine FGF21 Recombinant Protein - LS-G17049
E. coli Expression System

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Recombinant Protein
~50kDa (SDS-PAGE)
Human FGF-21 (aa 1-209) is fused at the C-terminus to the Fc portion of human IgG1.
aa 1-209
HEK 293 Cells
Human IgG1 Fc
Greater than 95% by SDS-PAGE
Activates ERK and FRS2alpha phosphorylation in bKlotho expressing cells.
Less than 0.1 EU/µg protein (determined by LAL method).
Store at +4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid repeat freeze-thaw cycles.
For research use only.

About FGF21

Q9NSA1 NM_019113 NP_061986.1

FGF21 Protein, Fibroblast growth factor 21 Protein, FGF-21 Protein

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.

Functional Assay

Functional Assay
ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. Klotho expressing cells were serum starved for 16 hours and then stimulated with hFGF-21-His (competitor), FGF-21-Fc and FGF-b (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: 1 ug/ml hFGF21-His (competitor) Lane 2: 2.2 ug/ml hFGF21-Fc (Prod. No. AG-40A-0095) Lane 3: 2.2 ug/ml mCD137-Fc (Prod. No. AG-40A-0025) Lane 4: 100ng/ ul FGF-b Lane 5: control (non-treated)

Requested From: United States
Date Requested: 10/22/2016

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