Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Recombinant Human ETS1 is produced by our E. coli expression system and the target gene encoding Met1-Thr272 is expressed with a 6His tag at the N-terminus.
Greater than 95% by SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from 0.2 µm filtered 20 mM PB, pH 7.4, 150 mM NaCl, 1 mM EDTA.
Lyophilized protein should be stored at less than -20°C. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at less than -20°C for 3 months.
ETS1 Protein, Ets protein Protein, ETS-1 Protein, EWSR2 Protein, p54 Protein, Protein C-ets-1 Protein
C-ets-1 is a nuclear ETS proto-oncogene product that activate transcription by interaction with purine-rich sequences present in the promoter/enhancer region of the T-Cell antigen receptor (TCRA) gene. In many cancers such as leukemia and lymphomas, the ETS-1 gene is either translocated or rearranged and amplified. In contrast, ectopic expression of ETS-1 in colon cancer cell lines that do not normally express the gene, suppresses tumorigenicity at a transcriptional level.