Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
72.4 kDa. DTT-reduced protein migrates as 90-110 kDa due to glycosylation
HEK 293 Cells
Greater than 95% by SDS-PAGE
Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. The ED50 for this effect is typically 5-45 ng/ml in the presence of 0.6 µg/ml goat anti-hErbB2.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from PBS, pH 7.4, 5-8% mannitol or trehalose
Centrifuge the vial before opening. Reconstitute in sterile PBS, pH 7.4 to 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, store at -20°C.
ERBB2 Protein, C-erb B2/neu protein Protein, CD340 Protein, HER2 Protein, Herstatin Protein, MLN 19 Protein, HER-2 Protein, Neu Protein, NGL Protein, Proto-oncogene c-ErbB-2 Protein, Proto-oncogene Neu Protein, CD340 antigen Protein, MLN19 Protein, p185erbB2 Protein, TKR1 Protein
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).