Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Measured by its binding ability in a functional ELISA. 1. Immobilized CD112-his at 20 µg/ml (100 µl/well) can bind biotinylated DNAM1 with a linear range of 0.078-2.5 µg/ml. 2. Immobilized CD112-Fc at 20 µg/ml (100 µl/well) can bind biotinylated DNAM1 with a linear range of 0.078-5 µg/ml. 2. Immobilized human CD155 at 20 µg/ml (100 µl/well) can bind human DNAM1 Fc chimera with a linear ranger of 1.28-160 ng/ml.
Lyophilized PBS, pH 7.4
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
DNAM-1 / CD226 is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants.